Inhoudsopgave - AthenaSummary
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AthenaSummary VrijeUniversiteitAmsterdam FaculteitderAard-enLevenswetenschappen–Bachelorjaar1 CelbiologieenImmunologie Boeksamenvatting - EssentialCellBiology,GarlandScience,Alberts,derdedruk Inhoudsopgave WEEK3-MHC-DIVERSITEIT,MIGRATIE,ANTI-TUMORTHERAPIE......................................................4 HOOFDSTUK5:THEMAJORHISTOCOMPATIBILITYCOMPLEX............................................................................4 HLAklasseIenIIgenen..................................................................................................................4 Andereeiwittenbetrokkeninantigeenverwerkingen-presentatie...............................................4 MHC-polymorfisme.........................................................................................................................5 MHC-diversiteitdoorinfectieziekten..............................................................................................6 HERHALINGDENDRITISCHECELLEN..............................................................................................................7 MHC-moleculen..............................................................................................................................8 Antigeenpresentatiedoordendritischecellen..............................................................................10 HOOFDSTUK17-KANKERENDEINTERACTIESMETHETIMMUUNSYSTEEM......................................................13 Kankeralsgevolgvanmutaties....................................................................................................13 Immuunresponstegenkanker......................................................................................................14 AllogeneverschilleninMHCklasseImoleculen............................................................................15 Tumorspecifiekeantigenen...........................................................................................................15 Succesvolletumorenontwijkenenmanipulerendeimmuunrespons...........................................15 Vaccinatietegenhethumanepapillomavirus(HPV)....................................................................16 Vaccinatiemettumorantigenen...................................................................................................16 Monoclonaleantilichamen...........................................................................................................17 Antilichaamsafhankelijkecellulairecytotoxiciteit(ADCC)............................................................17 Antigeengeactiveerdedendritischecellen....................................................................................18 Monoclonaleantilichamentegenceloppervlakte-antigenen.......................................................19 WEEK5-B-CEL-ENANTILICHAAMIMMUNITEIT.............................................................................20 HOOFDSTUK9:B-CEL-ENANTILICHAAMIMMUNITEIT..................................................................................20 AntilichaamproductiedoorB-lymfocyten.....................................................................................20 B-celactivatieencross-linkingvanimmunoglobulinen................................................................20 B-celco-receptor...........................................................................................................................21 B-celimmuniteitisafhankelijkvanCD4T-cellen...........................................................................21 Folliculairedendritischecellen......................................................................................................22 GeactiveerdeB-cellenverhuizennaarT-celgebieden...................................................................23 Klonaleexpansieindemedulla.....................................................................................................24 Somatischehypermutatieenisotypeswitching............................................................................24 Affiniteitsmaturatieindegerminalecentra.................................................................................25 IsotypeswitchingwordtbepaalddoorhelperT-cellen..................................................................27 HelperT-celcytokinenbepalendifferentiatietotplasmacellenofgeheugencellen......................27 HerhalingB-celdiversiteit..............................................................................................................28 Structurelebasisvanantilichaamdiversiteit.................................................................................28 GeneratievanimmunoglobulinediversiteitinB-cellen.................................................................28 Genherschikking...........................................................................................................................28 Somatischerecombinatie.............................................................................................................29 AlternatievemRNA-splitsing.........................................................................................................31 Somatischehypermutatie.............................................................................................................31 Isotypeswitching...........................................................................................................................32 Subklassenvanantilichamen........................................................................................................32 HOOFDSTUK9:B-CEL-ENANTILICHAAMIMMUNITEIT-DEEL2......................................................................33 IgM,IgGenmonomeerIgAbeschermendeinterneweefsels......................................................33 IgA-dimerenbeschermenmucosaleoppervlakten........................................................................33 IgEmechanismenvooruitstotingvanparasietenenpathogenen...............................................34 Overzichtvanmenselijkeimmunoglobulinenenhunfuncties......................................................36 Antilichamenvandemoeder........................................................................................................36 Neutraliserendeantilichamenvoorkomeninfecties.....................................................................37 WEEK6–CYTOSKELET...................................................................................................................38 HOOFDSTUK17:HETCYTOSKELET............................................................................................................38 Intermediairefilamenten..............................................................................................................38 Intermediairefilamentenversterkencellentegenmechanischestress........................................39 Hetnucleairemembraanwordtondersteunddoorintermediairefilamenten.............................40 Microtubuli...................................................................................................................................41 Microtubuliregulatiedoorcentrosoom.........................................................................................41 Dynamischeinstabiliteit...............................................................................................................42 DynamischeinstabiliteitisgedrevendoorGTP-hydrolyse............................................................42 Dynamischeinstabiliteitbeïnvloeddoormedicijnen....................................................................43 Microtubuliorganiserenhetcelinterieur......................................................................................43 Motoreiwittenregulerenintracellulairtransport.........................................................................43 Microtubulienmotoreiwittenplaatsenorganelleninhetcytoplasma........................................44 Ciliaenflagellahebbenmicrotubulidiebewegendoordyneïne..................................................44 Actinefilamenten..........................................................................................................................45 Actinefilamentenzijndunenflexibel............................................................................................46 Actineentubulinepolymeriserendoorvergelijkbaremechanismen............................................46 Eiwittenveranderenactine-eigenschappen..................................................................................47 Celcortex.......................................................................................................................................47 Actinebindtmyosineomcontractielestructurentevormen........................................................49 Extracellulairesignalenkunnenactinefilamentenveranderen.....................................................49 Spiercontractie..............................................................................................................................50 Actinefilamentenglijdenlangsmyosinefilamententijdenscontractie.........................................50 SpiercontractiewordtveroorzaaktdoorcytosolischCa2+.............................................................51 Verschillendesoortenspiercellenhebbenverschillendefuncties.................................................53 HOOFDSTUK20:CELGEMEENSCHAPPEN:WEEFSELS,STAMCELLENENKANKER.................................................54 Extracellulairematrixenbindweefsels.........................................................................................54 Plantencellenhebbenexternecelwanden....................................................................................54 Cellulosemicrofibrillengevenplantcelwandenrekbarekracht.....................................................55 Dierlijkbindweefselbestaatvoornamelijkuitextracellulairmatrix.............................................56 Collageenvoorzietbindweefselvanveerbarekracht...................................................................56 Cellenorganiserenhetcollageendatzeuitscheiden....................................................................57 Integrineskoppelendeextracellulairematrixaanhetcytoskelet................................................57 Polysaccharideneneiwittenvoorkomencompressie...................................................................58 Afgeplatepitheelenceljuncties....................................................................................................59 Epitheliazijngepolariseerdenrustenophetbasalelamina........................................................59 Strakkejuncties.............................................................................................................................60 Cytoskeletgebondenjuncties........................................................................................................60 Gapjuncties...................................................................................................................................61 Overzichtvandesoortenenfunctiesvanceljuncties...................................................................62 Weefselonderhoudenvernieuwing.............................................................................................62 2 Weefselszijngeorganiseerdemixenvanverschillendeceltypen..................................................62 Verschillendeweefselswordenvernieuwdmeteenverschillendetempo....................................63 Stamcellenverwekkeneencontinuevoorraadvangedifferentieerdecellen...............................63 Specifiekesignalenonderhoudenstamcelpopulaties...................................................................64 Stamcellenvoorweefselherstel....................................................................................................64 Therapeutischeklonenenvoortplantingsklonen..........................................................................65 Geïnduceerdepluripotentestamcellen.........................................................................................65 Kankercellenprolifereren,dringenbinnenenzaaienuit..............................................................66 Voorkombareoorzakenvankanker..............................................................................................66 Kankerontwikkelddooreenopeenhopingvanmutaties.............................................................66 Kankercelontwikkeling..................................................................................................................67 Oncogenenentumoronderdrukkergenen.....................................................................................68 Mutatiecascades...........................................................................................................................68 Behandeling..................................................................................................................................69 Inonsstrevennaarperfectiezettenwijallesopallesomeenvolledigesamenvattingbeschikbaar testellen.Mochtenwijonverhoopttochpuntenoverhethoofdhebbengezienofverkeerdhebben genoteerd, schroom dan niet dat terstond te melden. 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