CONgenital CORvitia

CONgenital CORvitia
Project group
BJM Mulder, AMC Amsterdam
ET van der Velde, LUMC Leiden
J Vis, ICIN
CJM Engelfriet-Rijk, ICIN
I Harms, ICIN
S Mantels, ICIN
Steering committee
BJM Mulder, chairman, ICIN
ET van der Velde, LUMC Leiden
ECM Mariman, AZM Maastricht
FJ Meijboom, Radboud UMC Nijmegen
HW Vliegen, LUMC Leiden
G Veen, VUMC Amsterdam
PG Pieper, UMC Groningen
HWM Plokker, St Antonius Hospital Nieuwegein
APJ van Dijk, Radboud UMC Nijmegen
JLM Stappers, AZM Maastricht
JW Roos-Hesselink, EMC Rotterdam
JGP Tijssen, AMC Amsterdam
RMF Berger, UMC Groningen
GJ Sieswerda, UMC Utrecht
National registry and DNA-bank of adults
with congenital heart disease
www.CONCOR.net
Number of participating hospitals: 103
Number of patients
Number of included patients:
10,035
12000
VSD
ASD
Aortic coarctation
Tetralogy of Fallot
Pulmonary valvar stenosis
Aortic valvar stenosis
Bicuspid aortic valve
Marfan syndrome
Total patients included
DNA obtained
10000
8000
6000
608
4000
531
Transposition of great arteries
ASD I
Subvalvar aortic stenosis
Ebstein
Congenital correction TGA
Pulmonary atresia +VSD
Mitral valval prolapse
Other diagnoses (<1%)
449
387 306
747
2000
932
-07
20
-01
1283
08
-07
08
20
-01
20
07
-07
07
20
-01
06
20
-07
20
06
-01
05
05
20
20
-01
-07
04
20
20
04
-07
-01
03
03
20
20
-07
20
02
02
-01
0
20
196
154
116
93
86
Year-Month
982
1474
Figure 1. Progress of inclusion.
1685
Figure 2. Most frequent main diagnoses.
40
30
20
10
All
University hospitals
Non-university hospitals
Congenital correction TGA
Ebstein
Subvalvar aortic stenosis
ASD I
Transposition of great arteries
Marfan syndrome
Bicuspid aortic valve
Aortic valvar stenosis
Pulmonary valvar stenosis
Tetralogy of Fallot
Aortic coarctation
ASD
0
VSD
Percentual increase in 2008
The CONCOR registry and DNA-bank aid in the unraveling of genes involved in congenital heart disease.
Main diagnosis
Figure 3. Increase in included patients in 2008, per main diagnosis.
Also: increase in university hospitals versus non-university hospitals
118
16-17 October 2008, CONCOR research nurses visited the
Maastricht University Medical Center. A total of 71 new
candidates were found; from 36 other patients blood was
obtained for the CONCOR DNA-bank.
Netherlands Heart Journal, Volume 17, Number 3, March 2009