Abstract

Timing van pick up
Zeer weinig literatuur
MP Rosen et al FertilSteril 2008
• Prospectief
• 235 cycli waarbij 2934 oocytes werden
gecollecteerd behorende tot 5 groepen naar
follikel grootte
• HCG trigger bij 2 follicles >= 18 mm
MII
2PN/OOCYTE
CELL N
FRAGMENTATION
>18 mm
89.9%
66%
6.91
2.48
16-18mm
78.7
56
6.78
2.68
13-15mm
72.9
48.7
6.65
2.87
10-12mm
53.0
35
6.88
2.74
<10mm
47.6
36.5
6.16
2.77
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Hum Fertil (Camb). 2012 Sep;15(3):134-9. doi: 10.3109/14647273.2012.712739.
Timing of human chorionic gonadotrophin (hCG) hormone administration in IVF protocols
using GnRHantagonists: a randomized controlled trial.
Morley L, Tang T, Yasmin E, Hamzeh R, Rutherford AJ, Balen AH.
Author information
Abstract
This randomized controlled trial investigated whether
delaying human chorionic gonadotrophin hormone (hCG) administration within an IVF cycle
impacts upon clinical outcomes. Participants included 125 women undergoing IVF/ICSI cycles
at Leeds Centre for Reproductive Medicine. Subjects were aged 20-36 years, body mass
index (BMI) 20-30 kg/m(2) with a normal FSH level (<8 IU/l). Administration of hCG took
place 35-36 h prior to oocyte retrieval when there were ≥3 follicles ≥17 mm in diameter
(Group A), delayed by 1 day (Group B) or 2 days (Group C). Outcomes included the number
of oocytes retrieved per cycle, fertilization rate and live birth rate. On the day of oocyte
retrieval, women in Groups B and C had significantly more mature follicles than Group A,
although the number of oocytes retrieved did not differ (median = 12 in each group).
Fertilization rates and embryo quality were comparable between groups. Pregnancies and
live births per cycle were higher in Groups B and C (A = 30.8%, B = 54.1%, C = 38.7%; A =
17.9%, B = 27.0%, C = 25.8%), but did not reach statistical significance. Delaying hCG
administration had no significant negative impact upon morphological quality of embryos,
availability of surplus embryos for freezing or pregnancy outcomes. Postponing hCG may
enable increased flexibility of cycle scheduling to avoid weekend procedures.
Comment in
Miller et al in Obs&Gyn 1996
• Retrospectief
• 50 pt voor en 50 na een verandering van
protocol
• HCG leading follicle 17mm  20mm
• Lang schema met agonisten
• No significant difference in pregnancy rate
(23% vs 36%)