social jetlag - NHG

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The association between social
jetlag, the metabolic syndrome
and type 2 diabetes mellitus in
the general population: the New
Hoorn study
Femke Rutters, PhD
Question?
Introduction
• Circadian rhythm
• Metabolism & Behavior
• Jetlag, shift work
Introduction
Social jetlag
AIM
To assess the association of social
jetlag with the metabolic
syndrome and type 2 diabetes
mellitus, in a population-based
cohort.
Materials and Methods
New Hoorn Study Cohort
Materials and Methods
Poisson and linear regression
Results
Social j <1 h
Social j 1-2h
Social j >2h
Number (n, %)
971
497
117
Sex (men %)
46
47
59
Age (years)
64 ± 6
57 ± 5
57 ± 5
Education level (low %)
6
3
2
Results
Metabolic syndrome
>61 y
Crude
Adjusted
<61 y
Social j 1-2h
1.13 (0.8; 1.6)
0.86 (0.6; 1.3)
Social j > 2h
1.19 (1.3; 2.9)
0.39 (0.1; 1.5)
Social j 1-2h
1.22 (0.8; 1.8)
1.04 (0.7; 1.6)
Social j > 2h
2.06 (1.3; 3.3)
0.58 (0.2; 2.2)
Results
Pre-diabetes
>61 y
<61 y
Social j 1-2h
1.35 (1.0; 1.8)
0.94 (0.7; 1.2)
Social j > 2h
1.79 (1.3; 2.5)
0.58 (0.3; 1.3)
Social j 1-2h
1.39 (1.0; 1.9)
0.89 (0.7; 1.2)
Social j > 2h
1.73 (1.2; 2.5)
0.54 (0.3; 1.2)
Crude
Adjusted
Discussion
• Social jetlag, 2x higher risk
• Younger population
• Jetlag, shift work
Discussion
Conclusion
In our population-based cohort social
jetlag was associated with a 2-fold
increased risk of the metabolic
syndrome and (pre-)diabetes mellitus,
especially in younger participants.
[email protected]
Take home message
Conclusion
In our population-based cohort social
jetlag was associated with a 2-fold
increased risk of the metabolic
syndrome and (pre-)diabetes mellitus,
especially in younger participants.
[email protected]