Diane De Neubourg - European Medicines Agency

Curriculum vitae
PERSONAL INFORMATION
Diane De Neubourg
WORK EXPERIENCE
August 2015–Present
Head of Department of Center for Reproductive Medicine
Antwerp University Hospital (Belgium)
Resaerch, Clinical activities and teaching.
May 2010–July 2015
Head of Clinic
University Hospitals Leuven (Belgium)
Resaerch, Clinical activities and teaching.
January 2006–April 2010
Head of Department of Center for Reproductive Medicine
ZNA Middelheim Hospital (Belgium)
Clinical activities
April 1998–December 2005
Member of staff-gynaecologist
ZNA Middelheim Hospital (Belgium)
Clinical activities
March 1996–March 1998
Member of staff - gynaecologist
Antwerp University Hospital (Belgium)
Clinical activities
EDUCATION AND TRAINING
September 1983–June 1990
Medical School
University of Antwerp (Belgium)
Medicine
September 1990–April 1995
Specialist training in Obstetrics and Gynaecology
Antwerp University Hospital (Belgium)
Obstetrics and Gynaecology and Reproductive Medicine
May 1995–March 1996
Master in Medical Sciences
University of Nottingham (Belgium)
Assisted Reproduction Technologies
November 2005–Present
PhD
University of Ghent (Belgium)
Single embryo transfer: clinical, obstetrical and neonatal impact.
ADDITIONAL INFORMATION
Expertise
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Reproductive Medicine
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Curriculum vitae
Diane De Neubourg
Assited reproduction technologies
Reproductive endocrinology
Andrology
Publications
Publications in peer reviewed international journals
 Ramael M, De Neubourg D, Van Steenlandt H, Van Marck E, Buytaert Ph. Endometrial papillary
carcinoma arising in a focus of adenomyosis. J Obstet Gynaecol 1992, 12, 278-279 (Impact factor:
0.546).
 Van Dam P, De Neubourg D, Renard J, Buytaert Ph. Laparoscopic treatment of adnexial torsion in
early pregnancy. J Obstet Gynaecol 1993, 13, 178 (Impact factor: 0.546).
 De Neubourg D, Robins A, Fishel S, Gibbon L Flow cytometric analysis of granulosa cells from
follicular fluid after follicular stimulation. Hum Reprod 1996, 11, 2211-2214 (Impact factor: 4.670).
 De Neubourg D, Robins A, Fishel S, Delbeke L Quantification of insulin like growth factor I
receptors on granulosa cells with flow cytometry after follicular stimulation. Hum Reprod 1998, 13,
161-164 (Impact factor: 4.670).
 Van Royen E, Mangelschots K, De Neubourg D, Valkenburg M, Van de Meerssche M, Ryckaert G,
Eestermans W, Gerris J Characterization of a top quality embryo, a step towards single embryo
transfer. Hum Reprod 1999, 14, 2345-2349 (Impact factor: 4.670).
 Gerris J, De Neubourg D, Mangelschots K, Van Royen E, Van de Meerssche M, Valkenburg M.
Prevention of twin pregnancy after in-vitro fertilization or intracytoplasmic sperm injection based on
strict embryo criteria: a prospective randomized clinical trial. Hum Reprod 1999, 14, 2581-2587
(Impact factor: 4.670).
 Van Royen E, Mangelschots K, De Neubourg D, Laureys I, Ryckaert G, Gerris J. Calculating the
implantation potential of day 3 in women younger than 38 years of age: a new model. Hum Reprod
2001, 16, 326-332 (Impact factor: 4.670).
 Gerris J, De Neubourg D, Mangelschots K, Van Royen E, Vercruyssen M, Barudy-Vasquez J,
Valkenburg M, Ryckaert G. Elective single day 3 embryo transfer halves the twinning rate without
decrease in the ongoing pregnancy rate of an IVF/ICSI programme. Hum Reprod 2002, 17, 26262631 (Impact factor: 4.670).
 Gerris J, Van Royen E, De Neubourg D, Mangelschots K, Valkenburg M, Ryckaert G. Impact of
single embryo transfer on the overall and twin-pregnancy rates of an IVF/ICSI programme. Reprod
Biomed Online 2001, 2, 172-177 (Impact factor: 2.675).
 De Neubourg D, Mangelschots K, Van Royen E, Vercruyssen M, Ryckaert G, Valkenburg M,
Barudy-Vasquez J, Gerris J. Impact of patients' choice for single embryo transfer of a top quality
embryo versus double embryo transfer in the first IVF/ICSI cycle. Hum Reprod 2002, 17, 2621-2625
(Impact factor: 4.670).
 Gerris J, De Neubourg D, De Sutter P, Van Royen E, Mangelschots K, Vercruyssen M.
Cryopreservation as a tool to reduce multiple birth. Reprod Biomed Online 2003, 7, 286-294 (Impact
factor: 2.675).
 De Neubourg D, Gerris J, Knaapen M, Kockx M. Human granulosa cells after ovulation induction
show caspase-independent cell death. Gynecol Obstet Invest 2003, 56, 106-112 (Impact factor:
1.103).
 Van Royen E, Mangelschots K, Vercruyssen M, De Neubourg D, Valkenburg M, Ryckaert G, Gerris
J. Multinucleation in cleavage stage embryos. Hum Reprod 2003, 18, 1062-1069 (Impact factor:
4.670).
 De Neubourg D, Gerris J. Single embryo transfer - state of the art. Reprod Biomed Online 2003, 7,
615-622 (Impact factor: 2.675).
 De Neubourg D, Gerris J, Mangelschots K, Van Royen E, Vercruyssen M, Elseviers M. Single top
quality embryo transfer as a model for prediction of early pregnancy outcome. Hum Reprod 2004, 19,
1476-1479 (Impact factor: 4.670).
 Gerris J, De Sutter P, De Neubourg D, Van Royen E, Vander Elst J, Mangelschots K, Vercruyssen
M, Kok P, Elseviers M, Annemans L, Pauwels P, Dhont M. A real-life prospective health economic
study of elective single embryo transfer versus two-embryo transfer in first IVF/ICSI cycles. Hum
Reprod 2004, 19, 917-923 (Impact factor: 4.670).
 De Neubourg D, Mangelschots K, Van Royen E, Vercruyssen M, Gerris J. Singleton pregnancies
are as affected by ovarian hyperstimulation syndrome as twin pregnancies. Fertil Steril 2004, 82,
1691-1693 (Impact factor: 4.174).
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Diane De Neubourg
 De Neubourg D, Gerris J. Can we eliminate ovarian hyperstimulation syndrome? Hum Reprod
2005, 20, 2369 (Impact factor: 4.670).
 Gerris J, De Neubourg D. (2005) Single embryo transfer after IVF/ICSI: present possibilities and
limits. J Obstet Gynecol Ind 2005, 55, 26-47.
 De Neubourg D, Gerris J, Mangelschots K ,Van Royen E, Vercruyssen M, Steylemans A, Elseviers
M. The obstetrical and neonatal outcome of babies born after single embryo transfer in IVF/ICSI
compares favourably to spontaneous conceived babies. Hum Reprod 2006, 21, 1041-1046 (Impact
factor: 4.670).
 De Neubourg D, Gerris J, Van Royen E, Mangelschots K, Vercruyssen M. Impact of a restriction in
the number of embryos transferred on the multiple pregnancy rate. Eur J Obstet Gynecol Reprod Biol
2006, 124, 212-215 (Impact factor: 1.843).
 De Neubourg D, Gerris J. What about the remaining twins since single embryo transfer? How far
can (should) we go? Hum Reprod 2006, 21, 843-846 (Impact factor: 4.670).
 Billet K, Dhont M, Vervaet C, Vermeire A, Gerris J, De Neubourg D, Delbeke L, Ombelet W, De
Sutter P. A multi-centre, prospective, randomized, double-blind trial studying the effect of misoprostol
on the outcome of intrauterine insemination. Gynecol Obstet Invest 2008, 66, 145-151 (Impact factor:
1.103).
 Pennings G, Autin C, Decleer W, Delbaere A, Delbeke L, Delvigne A, De Neubourg D, Devroey P,
Dhont M, D’Hooghe T, Lejeune B, Nijs M, Pauwels P, Perrad B, Pirard C, Vandekerckhove F. Crossborder reproductive care in Belgium. Hum Reprod 2009, 24, 3108-3118 (Impact factor: 4.670).
 De Neubourg D, Daels C, Elseviers M, Mangelschots K, Vercruyssen M, Van Royen E. Cumulative
live birth delivery after IVF/ICSI since the progressive introduction of single embryo transfer. Reprod
Biomed Online 2010, 20, 836-842 (Impact factor: 2.675).
 McLernon DJ, Harrild K, Bergh C, Davies MJ, De Neubourg D, Dumoulin JC, Gerris J, Kremer JA,
Martikainen H, Mol BW, Norman RJ, Thurin-Kjellberg A, Tiitinen A, van Montfoort AP, van
Peperstraten AM, Van Royen E, Bhattacharya S. Clinical effectiveness of elective single versus
double embryo transfer: meta-analysis of individual patient data from randomised trials. BMJ 2010,
341, c6945 (Impact factor: 17.215).
 Petro EM, Leroy JL, Covaci A, Fransen E, De Neubourg D, Dirtu AC, De Pauw I, Bols
PE.Endocrine-disrupting chemicals in human follicular fluid impair in vitro oocyte developmental
competence. Hum Reprod 2012, 27, 1025-1033 (Impact factor: 4.670).
 Willemen D, D'Hooghe T, Knoops I, De Neubourg D, Spiessens C. Does the European Union
Tissues and Cells Directive improve quality in the in vitro fertilization laboratory? A case study in a
tertiary referral center. Semin Reprod Med 2012, 30, 191-198 (Impact factor: 3.211).
 Valckx SD, De Pauw I, De Neubourg D, Inion I, Berth M, Fransen E, Bols PE, Leroy JL. BMIrelated metabolic composition of the follicular fluid of women undergoing assisted reproductive
treatment and the consequences for oocyte and embryo quality. Hum Reprod 2012, 27, 3531-3539
(Impact factor: 4.670).
 De Neubourg D, van Duijnhoven NT, Nelen WL, D'Hooghe TM. Dutch translation of the ICMARTWHO revised glossary on ART terminology. Gynecol Obstet Invest 2012, 74, 233-248 (Impact factor:
1.103).
 Paternot G, Debrock S, De Neubourg D, D'Hooghe TM, Spiessens C. Semi-automated
morphometric analysis of human embryos can reveal correlations between total embryo volume and
clinical pregnancy. Hum Reprod 2013, 28, 627-633 (Impact factor: 4.670).
 Dancet EA, D'Hooghe TM, Spiessens C, Sermeus W, De Neubourg D, Karel N, Kremer JA, Nelen
WL. Quality indicators for all dimensions of infertility care quality: consensus between professionals
and patients. Hum Reprod 2013, 28, 1584-1597 (Impact factor: 4.670).
 De Neubourg D, Bogaerts K, Wyns C, Albert A, Camus M, Candeur M, Degueldre M, Delbaere A,
Delvigne A, De Sutter P, Dhont M, Dubois M, Englert Y, Gillain N, Gordts S, Hautecoeur W, Lesaffre E,
Lejeune B, Leroy F, Ombelet W, Perrier D’Hauterive S, Vandekerckhove F, Van der Elst J, D’Hooghe
T. The history of Belgian assisted reproduction technology cycle registration and control: a case study
in reducing the incidence of multiple pregnancy. Hum Reprod 2013, 28, 2709-2719 (Impact factor:
4.670).
 Paternot G, Debrock S, De Neubourg D, D’Hooghe T. Spiessens C. The spatial arrangement of
blastomeres at the 4-cell stage and IVF outcome. Reprod Biomed Online 2014, 28, 198-203 (Impact
factor: 2.675).
 Peeraer K, Debrock S, Laenen A, De Loecker P, Spiessens C, De Neubourg D, D’Hooghe T. The
impact of legally restricted embryo transfer and reimbursement policy on cumulative delivery rate after
treatment with assisted reproduction technology. Hum Reprod 2014, 29, 267-75 (Impact factor:
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Curriculum vitae
Diane De Neubourg
4.670).
 De Neubourg D, Bogaerts K, D’Hooghe T. Reply: Legislation of embryo transfer effected the
denominator not the numerator. Hum Reprod 2014, 29, 382 (Impact factor: 4.670).
 Servaes K, Van Schoubroeck D, Welkenhuysen M, D’Hooghe T, De Neubourg D. How
reproducible are 2-dimensional ultrasonographic follicular diameter measurements from stored 3dimensional files of ovarian scanning? Gynecol Obstet Invest 2014, 77, 163-8 (Impact factor: 1.103).
 De Neubourg D, Peeraer K, Debrock S, D’Hooghe T. Belgium model of coupling reimbursement of
ART costs to restriction in number of embryos transferred. BMJ 2014, 348, g1559 (Impact factor:
17.215).
 De Neubourg D. Reply: The danger of ignoring pregnancy and delivery rates in ART. Hum Reprod
2014, 29, 1830-1 (Impact factor: 4.670).
 Petro EML, D’Hollander W, Covaci A, Bervoets L, Fransen E, Leroy LMRJ, De Neubourg D, De
Pauw I, Bols PEJ. Perfluoroalkyl acid contamination of follicular fluid and its consequence for in vitro
oocyte developmental competence. Sci Total Environ 2014, 15; 282-8. (Impact factor: 3.163).
 Peeraer K, Debrock S, De Loecker P, Tomassetti C, Laenen A, Welkenhuysen M, Meeuwis L,
Pelckmans S, Mol BW, Spiessens C, De Neubourg D, D'Hooghe TM. Low-dose human menopausal
gonadotrophin versus clomiphene citrate in subfertile couples treated with intrauterine insemination: a
randomized controlled trial. Hum Reprod. 2015, 30, 1079-88 (Impact factor: 4.670).
 Neyens S, De Neubourg D, Peeraer K, De Jaegher N, Spiessens C, Debrock S, De Loecker P,
D’Hooghe TM. Is there a correlation between the number of follicular flushings, oocyte/embryo quality
and pregnancy rate in ART cycles? Results from a prospective study. Gynaecol Obstet Invest, 2015,
accepted (Impact factor: 1.103).
 Debrock S, Peeraer K, Fernandez Gallardo E, De Neubourg D, D’Hooghe TM, Spiessens C.
Vitrification of cleavage stage day 3 embryos results in higher live birth rates than slow freezing: a
randomised controlled trial. Hum Reprod. 2015, 30:1820-30. (Impact factor: 4.670).
 Peeraer K, Couck I, Debrock S, De Neubourg D, De Loecker P,Tomassetti C, Laenen A,
Welkenhuysen M, Meeuwis L, Pelckmans S,Meuleman C, D'Hooghe T. Frozen-thawed embryo
transfer in a natural or mildly hormonally stimulated cycle in women with regular ovulatory cycles: a
RCT. Hum Reprod. 2015,30:2552-62. . (Impact factor: 4.670).
 Van Schoubroeck D, Raine-Fenning N, Installé AJ, De Neubourg D,De Moor B, Bourne T, Van den
Bosch T, Timmerman D. Interobserver agreement in assessing polycystic ovarian morphology using
pattern recognition. Ultrasound Obstet Gynecol. 2015 Sep 29.
 De Neubourg D, Bogaerts K, Blockeel C, Coetsier T, Delvigne A, Devreker F, Dubois M, Gillain N,
Gordts S, Wyns C. How do cumulative live birth rates and cumulative multiple live birth rates over
complete courses of assisted reproductive technology treatment per woman compare among
registries? Hum Reprod. 2016;31(1):93-9.
 Chen F, De Neubourg D, Debrock S, Peeraer K, D'Hooghe T, Spiessens C. Selecting the embryo
with the highest implantation potential using a data mining based prediction model. Reprod Biol
Endocrinol. 2016;14(1):10.
 Peeraer K, D'Hooghe T, Laurent P, Pelckmans S, Delvigne A, Laenen A, Welkenhuysen M, Wyns
C, De Neubourg D. Impact of luteal phase support with vaginal progesterone on the clinical pregnancy
rate in intrauterine insemination cycles stimulated with gonadotropins: a randomized multicenter study.
Fertil Steril. 2016;106(6):1490-1495.
Publications in peer reviewed national journals
 De Neubourg D,Yves Jacquemyn,Philippe Buytaert. Serotiniteit : is overtijd uit de tijd ?Tijdschrift
voor geneeskunde-ISSN0371-683X-48(1992)p.1641-1644
 M. Coppens, De Neubourg D,Philippe Buytaert,L. Dykmans. Place des fluoroquinolones dans le
traitement des infections gynécologiques
Tijdschrift voor geneeskunde-ISSN0371-683X-49(1993)p.22-26
 M. Coppens, De Neubourg D,Philippe Buytaert,L. Dykmans. De plaats van de fluoroquinolones in
de behandeling van gynaecologische infecties
Tijdschrift voor geneeskunde-ISSN0371-683X-49(1993)p.1476-1480
 De Neubourg D,Philippe Buytaert. Fysiologie van de lactatie
Tijdschrift voor geneeskunde-ISSN0371-683X-49(1993)p.1346-1348
 M. Henskens, De Neubourg D,Philippe Buytaert. Hormonale substitutie bij postmenopauzale
vrouwen met borstkanker in de voorgeschiedenis
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Diane De Neubourg
Tijdschrift voor geneeskunde-ISSN0371-683X-50(1994)p.1653-1658
 M. Coppens,Y. Leroy,Philippe Buytaert, De Neubourg D,E. Elst,Ludo Mahieu.
Meerlingzwangerschap : de wijze van bevalling
Tijdschrift voor geneeskunde-ISSN0371-683X-50(1994)p.1919-1926
 Y. Leroy,M. Coppens,Philippe Buytaert, De Neubourg D,E. Elst,Ludo Mahieu. De begeleiding van
meerlingzwangerschap.
Tijdschrift voor geneeskunde-ISSN0371-683X-50(1994)p.1913-1918.
 F. Vermeersch,J. Loor, de, De Neubourg D,Philippe Buytaert. Primaire lactatieremming. Tijdschrift
voor geneeskunde-ISSN0371-683X-52(1996)p.528 Clasen K, De Neubourg D, De Sutter P, D’Hooghe T, Gerris J, Gordts S, Ombelet W, Spiessens C,
Stoop D, Tournaye H, Vanderschueren D. Donorinseminatie: klassieke inseminatie met cervixkapje
(KID) of intra-utereine inseminatie met opgewekt donorsperma (IUI-D)? Een technische of een
praktische kwestie? Gunaikeia 2004, 9, 12-17.
 De Neubourg D, Gerris J, Van Royen E, Mangelschots K, Valkenburg M. Prevention of twin
pregnancy after IVF/ICSI using single embryo transfer. Verh K Acad Geneesk Belg 2002, 64, 361370.
 Lebbe B, De Neubourg D, Lagrou K, D’Hooghe T. Is screening voor Chlamydia Trachomatis in de
subfertiliteitsdiagnostiek nuttig? Gunaikeia 2014, 19,8-15.
 Coetsier T, Inion I, Peeraer K, Pelckmans S, Vandekerckhove F, Verpoest W , De Neubourg D
(VWRG) . Meeting A en B centra : een discussie over de opheffing van de anonimiteit van donoren.
Gunaikeia 2016, 21, 6-9.
Projects
Postdoctoraal klinisch onderzoeksfonds (KOF) van UZ Leuven, 2013- 2015.
Fonds voor Wetenschappelijk Onderzoek, “Analysis of genetic heterogeneity in the human blastocyst”
(G092415N) vanaf 1/1/2015 (co- promotor).
Fonds voor Wetenschappelijk Onderzoek, TBM project“How does detection of DNA damage in sperm
influence the patient’s chance of conception? ” (T007016N) since 1/10/2016.
Memberships
Member of the Vlaamse Vereniging voor Gynaecologie en Obstetrie (VVOG) since 1990.
Member of the Koninklijke Belgische Vereniging voor Gynaecologie en Verloskunde (K.B.V.G.V.) since
1990.
Member of the International Society of Obstetricians and Gynaecologists (F.I.G.O.) since 1990.
Member of the European Society for Human Reproduction and Embryology (ESHRE) since 1996.
Member of the Belgian Society for Reproductive Medicine (BSRM) since 2000.
Member of the American Society for Reproductive Medicine (ASRM) since 2006.
Secretary of the College of Physicians for Reproductive Medicine (2000-2007 and 2013-2014).
Vice- President of the College of Physicians for Reproductive Medicine (since 2014).
Member of the Committee for Registration of the College of Physicians for Reproductive Medicine
(2005-2008 and since 2015)
Member of the Vereniging voor Fertiliteitsstudie (VFS) since 1998 and member of the Board of VFS
from 2000-2008 (treasurer).
Member of the Vlaamse Werkgroep voor Reproductieve Geneeskunde (VWRG) since 2010.
President of the Vlaamse Werkgroep voor Reproductieve Geneeskunde (VWRG) (2013-2016).
Other Relevant Information
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